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CTT ECOIND

ECO-PHARMA

Solutii eco-friendly pentru monitorizarea si protectia biodiversitatii sistemelor integratoare, precum si pentru preventia distrugerii acestora – ECO-PHARMA

  • Responsabil proiect: Dr. Biol. Mihai NITA-LAZAR Scurta descriere: Poluarea cu substante farmaceutice, in special cele cu efect antimicrobian, reprezinta o tema de actualitate deoarece, in ciuda faptului ca acestea controleaza infectiile generate de bacteriile patogene, se acumuleaza in mediul inconjurator, generand fenomenul de rezistenta la antibiotice si ajungand sa perturbe echilibrul intregii biote. Proiectul propune cercetarea unor solutii prietenoase cu mediul, care sa inlocuiasca substantele farmaceutice sintetice cu efect antimicrobian si sa obtina noi produse vegetale cu efect antimicrobian potentat. Pentru identificarea efectelor noilor produse, se propun metode noi de monitorizare si evaluare predictiva a efectului toxic al poluantilor si implicit al impactului lor asupra biodiversitatii, utilizand diverse tipuri de bioindicatori care pornesc de la nivel transcriptional, translational si ajung pana la nivelul de celule procariote si eucariote.

Faza 1/2023:

  • Studiu in silico privind raspandirea si impactul generat de substantele farmaceutice in mediul inconjurator;
  • Studiu de evidentiere a stadiului actual al cunoasterii privind metodele alternative versus metodele conventionale de identificare a biodiversitatii;
  • Protocol de lucru in teren pentru analiza eDNA 4. Studiul de caracterizare a impactului substantelor farmaceutice cu efect poluator asupra plantelor cu potential antimicrobian.

Faza 2/2023:

  • Studiu experimental de caracterizare ecotoxicologica a compusilor farmaceutici;
  • Protocol de lucru teste de toxicitate/ histopatologie si profile proteice ;
  • Baza de date cu tulpini din microbiota intestinala a pestilor rezistente la antibiotic;
  • Studiu experimental de analiza la nivel molecular a unor fitobiomarkeri de stress;
  • Metoda de obtinere a unor compusi din extracte vegetale cu efect potential antimicrobian ;
  • Studiu experimental de caracterizare a compozitiei si structurii comunitatilor biotice de la nivelul unor sisteme acvatice selectate;
  • Metodologie specifica de analiza a tipurilor de polen.

Faza 3/2024

  • Studiu experimental de evaluare a efectelor antimicrobiene a extractelor eco-friendly comparativ cu compusii farmaceutici existenti 

Faza 3/II/2024

  • Studiu experimental de evaluare a efectelor antimicrobiene a extractelor de salvie comerciale si preparate in laborator comparativ cu compusii farmaceutici existenti

Faza 4/2024

  • Studiu privind implementarea in laborator a metodelor de determinare a CCOCr si CBO5 aliniate la standadele internationale in vigoare
  • Studiu experimental de evaluare a capacitatii de degradare a noilor compusi eco-friendly pe baza de salvie
  • Protocol de lucru pentru analize CCOCr si CBO5

Faza 4/II/2024

  • Studiu experimental de evaluare a efectelor ecotoxicologice pentru extractele preparate din salvie

Faza 5/2025:  Dezvoltarea de noi metode moderne de biomonitoring a impactului antropic generat de substante farmaceutice cu efect antimicrobian asupra biodiversitatii mediului inconjurator

Faza 6.1/2025:  Validarea noilor metode de biomonitoring a biodiversității în comparație cu metodele standard      

Faza 5/2025

  • Metodologie de analiza a biodiversitatii prin tehnici alternative (eDNA)
  • Metodologie de lucru conform OECD Test Guideline no. 249:2021
  • Studiu de biomonitorizarea a particulelor de polen ca bioindicator al biodiversitatii
  • Studiu de caracterizare microbiologica a calitatii aerului corelata cu densitatea de polen

Faza 6.1/2025:

  • Studiu experimental privind utilizarea liniilor celulare din țesuturi de pește în testele de toxicitate acvatică 
  • Articole
  1. The Effects of CO2-Enriched Water Irrigation on Agricultural Crop Growth – Laura Feodorov, Anca Maria Patrascu, Alina-Roxana Banciu, Dragos Radulescu, Catalina Stoica, Indraneel Sen, Yasmina Dimitrova , Matteo Fasano, Mihai Nita-Lazar, Agriculture 2025, 15(11), 1222; https://doi.org/10.3390/agriculture15111222;
  2. The analysis of tetracycline impact on aquatic systems by in vitro ecotoxicity tests, Laura Feodorov, Marcela Popa, Mihai Nita-Lazar, Petronela Ardelean (Munteanu), Calina Petruta Cornea, RJEEC, in press.
  3. COVID-19 Pandemic Modulates the Environmental Contamination Level of Enteric Bacteria from WWTPs. Banciu, A.R.; Pascu, L.F.; Stoica, C.; Gheorghe, S.; Lucaciu, I.; Feodorov, L.; Nita-Lazar, M. Water 2024, 16, 1092, Q2, FI 3,4 https://doi.org/10.3390/w16081092
  4. The COVID-19 Pandemic Impact of Hospital Wastewater on Aquatic Systems in Bucharest. Banciu, A.R.; Pascu, L.F.; Radulescu, D.M.; Stoica, C.; Gheorghe, S.; Lucaciu, I.; Ciobotaru, F.V.; Novac, L.; Manea, C.; Nita-Lazar, M. Water 2024, 16, 245, Q2, FI 3,4. https://doi.org/10.3390/w16020245

 

  • Manisfestari stiintifice
  1. Ecotoxicity of sulfamethoxazole: impact on freshwater ecosystems and oxidative stress in fish, Stefania Gheorghe, Catalina Stoica, Laura Feodorov, Vasile Ion Iancu, Daniel Gheorghe Rudaru, Anca Maria Patrascu, Mihai Nita-Lazar, INCREaSE 2025, International Congress on Engineering and Sustainability in the XXI Century, 01.07-04.07.2025, Faro, Portugalia.
  2. eDNA Metabarcoding as an Alternative Tool for Biodiversity Monitoring in Romanian Freshwater Ecosystems, Catalina Stoica, Mihai Nita-Lazar, INCREASE 2025, International Congress on Engineering and Sustainability in the XXI Century, 01.07-04.07.2025, Faro, Portugalia.
  3. Environmental impact assessment of tetracycline contamination in freshwater aquatic systems: acute and chronic toxicity, Stefania Gheorghe, Laura Feodorov, Catalina Stoica, Anca Maria Patrascu, Mihai Nita -Lazar, 2nd Global Conference on Environmental Science and Technology (GEST 2025), 15.10-17.10.2025 Roma, Italia.
  4. Cytotoxic effects of Salvia officinalis extract on fish gill cells: a preliminary study using RTGILL-W1, Stefania Gheorghe, Madalina Andreea Badea, Laura Feodorov, Mihaela Balas, The 28th International Symposium “Environment and Industry”, OCTOBER 23rd – 24th, 2025.
  5. An aquatic system multi-level evaluation using species-specific sensitivity bioindicators, Laura Feodorov, Stefania Gheorghe, Mihai Nita-Lazar, Călina-Petruța Cornea, One Health International Student Conference, 3-5 December 2025, Bucharest.
  6. Insights on aquatic biodiversity as a result of “urban stream syndrome” , Catalina Stoica, Ana-Maria Fulgheci, Anca-Maria Patrascu, Daniel Gheorghe Rudaru, Nicoleta Vasilache, Mihai Nita-Lazar, 2nd Global Conference on Environmental Science and Technology October 15-17, 2025, Rome Italy.
  7. TiO₂ Nanoparticles as photocatalysts for the degradation of the organic compounds, Ana-Maria Fulgheci, Roxana-Doina Trusca, Ludmila Motelica, Cristina Uncu, Denisa Ficai, Ovidiu-Cristian Oprea, Anton Ficai, Symposium of Chemical Engineering and Materials (SICHEM 2025)
  8. The Analysis of Tetracycline Impact on Aquatic Systems by In Vitro Ecotoxicity Tests, Laura Feodorov, Marcela Popa, Mihai Nita-Lazar, Petronela Ardelean (Munteanu), Calina Petruta Cornea, The 28th International Symposium “Environment and Industry”, OCTOBER 23rd – 24th, 2025
  9. Antibiotic stress responses in aquatic bioindicator species, Anca-Maria Pătrașcu, Stefania Gheorghe, Laura Feodorov, Mihai Nita-Lazar, The 28th International Symposium  “Environment and Industry”, OCTOBER 23rd – 24th, 2025
  10. eDNA – a novel approach for monitoring the aquatic macroinvertebrates diversity. C. Stoica, L.D. Ionica, S. Gheorghe, A.R. Banciu, D.M. Radulescu, L. Novac, F.V. Ciobotaru, A.M. Harabagiu, A.M Fulgheci, D. Rudaru. E.D. Mighiu, I.E. Lucaciu, M. Nita-Lazar. Conferinta Internationala 10th International Conference on Environmental Management, Engineering, Planning and Economics (CEMEPE 2023) and SECOTOX 5-9.06 2023, Grecia, Skiatos. 2023.
  11. Evaluation of the tetracycline effects on the aromatic plants with antimicrobial effect. Laura Novac, Anca Harabagiu., Ana Fulgheci, Dragos Radulescu, Alina Banciu, Daniel Rudaru, Emanuel Mighiu, Catalina Stoica, Stefania Gheorghe, Irina Lucaciu, Mihai Nita-Lazar. International Symposium” The Environment and the industry”, 26-27 09.2023 Bucuresti. 2023.
  12. Sulfamethoxazole phytotoxic effects on germination and growth of some aromatic plants. Anca-Maria Harabagiu, Laura Novac, Emanuel-Daniel Mighiu, Ana Fulgheci, Dragos Radulescu, Alina Banciu, Daniel Rudaru, Catalina Stoica, Stefania Gheorghe, Irina Lucaciu, Mihai Nita-Lazar. International Symposium” The Environment and the industry”, 26-27 09.2023 Bucuresti. 2023.
  13. Comparative study of cod parameter measured using two different standard methods. Ana-Maria Fulgheci, Daniel Rudaru, Alexandra Stavarache, Irina Eugenia Lucaciu. International Symposium” The Environment and the industry”, 26-27 09.2023, Bucuresti. 2023.
  14. Impact of environmental variables on benthic invertebrates community structure in Comana Marsh, Romania. Catalina Stoica, Gabriela Ioana-Tomoimac, Ionut Andrei Sandor, Gabriela Adina Morosanu, Dana-Maria Constantin, Ana-Maria Fulgheci, Iuliana Paun, Florinela Pirvu, Laura Florentina Chiriac and Mihai Nita Lazar. Climate Change in Europe: Impact, Risks and Mitigation/ CCE 2024 – Book of abstract. 2024.
  15. Monitoring the microplastics impacts on Cyprinus carpio by biomarkers expression at translational level. Catalina Stoica, Stefania Gheorghe, Alina Banciu, Mihai Nita-Lazar. 38th BARCELONA International Conference on “Chemical, Biological and Environmental Sciences” (BCBES-24) April 24-26, 2024 Barcelona (Spain) – poster. 2024.
  16. Ecotoxicological Impact of Antibiotics on Aquatic Ecosystems. Laura Feodorov, Stefania Gheorghe, Anca-Maria Patrascu, Ana Maria Fulgheci, Alina Roxana Banciu, Mihai Nita-Lazar. International Conference on Environment and Life Science (ICELS-24), 4th – 5th November 2024, Milan, Italy, 2024.
  17. Antimicrobial activity of citrus semivolatile compounds obtained through a new enzyme assisted extraction technique. Laura Feodorov, Anca-Maria Patrascu, Daniel Rudaru, Dragos Mihai Radulescu, Alina Roxana Banciu, Mihai Nita-Lazar. International Symposium ”The Environment and the industry” Constanta 2024 https://www.simiecoind.ro/wp-content/uploads/2024/09/SCIENTIFIC-PROGRAM-SIMI-2024.pdf;. 2024.
  18. Exploring Current Frontiers of Environmental challenges by Bioindicators and Biomarkers. Laura Feodorov, Mihai Nita-Lazar, Calina Petruta Cornea. ,,The International Conference of the University of Agronomic Sciences and Veterinary Medicine of Bucharest, Agriculture for life, life for Agriculture’’, June, 2024, poster. 2024.
  19. Assessment of the efficiency of a municipal wastewater treatment plant from Romania. A case study. Ana-Maria Fulgheci, Daniel-Gheorghe Rudaru, Marta Andrei, Florinela Pirvu, Nicoleta Vasilache, Iuliana Paun. 27th International Symposium „Environment and Industry”, 19th – 20th September 2024. 2024.
  20. Antimicrobial activity of rosemary semivolatile compounds obtained through a new enzyme assisted extraction technique. Anca-Maria Patrascu, Laura Feodorov, Daniel Rudaru, Dragos Mihai Radulescu, Alina Roxana Banciu, Mihai Nita-Lazar. International Conference on Environment and Life Science (ICELS-24), 4th – 5th November 2024, Milan, Italy. 2024.
  21. Ecotoxicity of sulfamethoxazole: impact on freshwater ecosystems and oxidative stress in fish. Stefania Gheorghe, Catalina Stoica, Laura Feodorov, Vasile Ion Iancu, Daniel Gheorghe Rudaru, Anca Maria Patrascu, Mihai Nita-Lazar. INCREASE 2025, International Congress on Engineering and Sustainability in the XXI Century, 01.07-04.07.2025, Faro, Portugalia.. 2025.
  22. Insights on aquatic biodiversity as a result of “urban stream syndrome”. Catalina Stoica, Ana-Maria Fulgheci, Daniel Gheorghe Rudaru, Nicoleta Vasilache, Mihai Nita-Lazar. 2nd Global Conference on Environmental Science and Technology (GEST 2025), 15.10-17.10.2025 Roma, Italia, 2025.
  23. An aquatic system multi-level evaluation using species-specific sensitivity bioindicators. Laura Feodorov, Stefania Gheorghe, Mihai Nita-Lazar, Călina-Petruța Cornea. One Health International Student Conference, 3-5 December 2025, Bucharest, 2025.

 

  • Alte activități de promovare sau bază de cunoaștere pentru proiecte de cercetare
  1. Evaluarea siguranței ecologice a ingredientelor obținute din subproduse agroalimentare– prezentare orala – Workshop| 5 iunie2025 pe tema ,,Valorificarea subproduselor agroalimentare – oportunități si provocări in conceptul One Health’’;
  2. Participare la Focus Grup nr. 3 si 4 organizat în cadrul proiectului ADER 16.1.2 – „Cercetări privind elaborarea unei scheme de certificare pe lanțul alimentar conform conceptului One Health”.
  3. Prezentare rezultat de cercetare – Revista Magurele Science Park: Metodologie de evaluare ecotoxicologică a extractului vegetal de Salvia officinalis cu eficiență antibacteriană, Laura Feodorov, Ștefania Gheorghe.  Link acces: Metodologie de evaluare ecotoxicologică a extractului vegetal de Salvia officinalis cu eficiență antibacteriană – MSP
  4. Propunere proiect international Call: HORIZON-CL6-2025-01, Topic: HORIZON-CL6-2025-01-ZEROPOLLUTION-05, Proposal number: 101286793, Innovative Marine Pollution Assessment and Cleanup Technologies – EU-India.
  5. Propunere de proiect Water4All 2025 Joint Transnational Call, HYDRO-PLAST: Smart Retention and Monitoring of Microplastics and Contaminants of Emerging Concerns for Run-of-River Hydropower Systems
  6. Propunere proiect HORIZON EUROPE – HORIZON-CL6-2024-CIRBIO-02 Carbon negative, decentralised water treatment solution valorised for agriculture and beyond, Propunerea nr.101182317-1, AWARE
  7. Propunere proiect HORIZON EUROPE – Horizon-MSCA-2024-DN-01, Training Experts in Light-Based Additive Manufacturing, acronym TEAM, Propunerea nr. 101227713, TEAM